Minoxidil (U-10858) is a selective ATP dependent K+ channel (Kir6) activator. As a result membrane permeability increases the flow of K+ across the membrane, which turns off voltage gated calcium channels. This inhibition in action potential causes a relaxation in arteriolar smooth muscle. Alternate studies indicate that Minoxidil (U-10858) activates the β-catenin pathway in human dermal papilla cells which results in accumulation of β-catenin in the nucleus.
MINOXIDIL
Structure
Product Description
Details |
|
|---|---|
Chemical Name |
MINOXIDIL |
IUPAC Name |
6-Piperidin-1-ylpyrimidine-2,4-diamine 3-oxide |
CAS Number |
38304-91-5 |
Molecular Formula |
C9H15N5O |
Synonyms |
pdp;regain;lonolox;alostil;regaine;rogaine;U-10858;loniten;alopexil;prexidil |
Application |
A selective ATP dependent K+ (Kir6) channel activator. |